2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-179587
    1,2,3-Triazole-PEG8-amine
    JQ-1 (carboxylic acid)-amine-PEG8-cyanogen is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    1,2,3-Triazole-PEG8-amine
  • HY-138500
    Mal-PEG12-NH-Boc 2170654-80-3
    Mal-PEG12-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG12-NH-Boc
  • HY-140784
    Azido-PEG16-Boc
    Azido-PEG16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG16-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG16-Boc
  • HY-135938
    NH2-PEG5-C1-Boc 2231845-67-1
    NH2-PEG5-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG5-C1-Boc
  • HY-138331
    Fmoc-N-amido-PEG6-amine
    Fmoc-N-amido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-N-amido-PEG6-amine
  • HY-143837
    Acid-PEG12-t-butyl ester
    Acid-PEG12-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG12-t-butyl ester
  • HY-140770
    Azido-PEG3-aminoacetic acid-NHS ester 2170240-91-0
    Azido-PEG3-aminoacetic acid-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-aminoacetic acid-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-aminoacetic acid-NHS ester
  • HY-140852
    Azido-PEG3-methyl ester 2086689-07-6
    Azido-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-methyl ester
  • HY-168309
    7-(Piperidin-4-ylmethyl)-2,7-diazaspiro[3.5]nonane 2894098-26-9
    7-(Piperidin-4-ylmethyl)-2,7-diazaspiro[3.5]nonane is the PROTAC linker of FHD-609 (HY-153367).
    7-(Piperidin-4-ylmethyl)-2,7-diazaspiro[3.5]nonane
  • HY-118411S
    5-Ethynyl-2'-deoxyuridine-13C 1610530-40-9
    5-Ethynyl-2'-deoxyuridine-13C1 (EdU-13C1) is the 13C-labeled 5-Ethynyl-2'-deoxyuridine (HY-118411). 5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    5-Ethynyl-2'-deoxyuridine-<sup>13</sup>C
  • HY-132859
    Bromo-C10-OBn 78277-30-2
    Bromo-C10-OBn is a PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-C10-OBn
  • HY-130690
    Propargyl-PEG1-SS-PEG1-C2-Boc 1807518-78-0 98.0%
    Propargyl-PEG1-SS-PEG1-C2-Boc is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-SS-PEG1-C2-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG1-SS-PEG1-C2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG1-SS-PEG1-C2-Boc
  • HY-140750
    Benzyloxy carbonyl-PEG3-C2-Boc 1835759-86-8
    Benzyloxy carbonyl-PEG3-C2-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyloxy carbonyl-PEG3-C2-Boc
  • HY-140450
    Diketone-PEG12-DBCO
    Diketone-PEG12-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Diketone-PEG12-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Diketone-PEG12-DBCO
  • HY-140769
    Azido-PEG5-succinimidyl carbonate 1402411-88-4
    Azido-PEG5-succinimidyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-succinimidyl carbonate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-succinimidyl carbonate
  • HY-134710
    Benzyl-PEG24-alcohol 2218463-19-3
    Benzyl-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG24-alcohol
  • HY-130897
    Boc-NH-PEG11-CH2CH2N3 2395004-21-2
    Boc-NH-PEG11-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG11-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-NH-PEG11-CH2CH2N3
  • HY-140387
    Ms-PEG12-Boc
    Ms-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ms-PEG12-Boc
  • HY-132012
    Benzyl-PEG9-acid
    Benzyl-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG9-acid
  • HY-140156
    Methylamino-PEG4-Boc 1621616-14-5
    Methylamino-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methylamino-PEG4-Boc
PROTAC Linkers Isoform Comparison

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